IMMUNOCHEMICAL IDENTIFICATION OF PARATHYROID HORMONE IN NON-PARATHYROID NEOPLASMS ASSOCIATED WITH HYPERCALCEMIA
نویسندگان
چکیده
منابع مشابه
Immunochemical Identification of Parathyroid Hormone in Non-parathyroid Neoplasms Associated with Hypercalcemia
1. Immunochemical cross-reactivity, but not identity, has been demonstrated between bovine parathyroid hormone and an antigen in biologically active extracts of human parathyroid tissue by quantitative C' fixation and C' fixation inhibition. 2. An antigen that fixes C' with rabbit antibody to bovine parathyroid hormone has been found in urea extracts of six human non-parathyroid neoplasms assoc...
متن کاملHypercalcemia associated with a parathyroid cyst.
A fifty eight year old man undergoing routine investigations was found to have hypercalcaemia. His calcium level was elevated to 3.63 mmol/l and the serum parathyroid hormone level was 18.4 pmol/l (normal range 1.0 5.3 ). Serum alkaline phosphatase was at the upper limit of normal at 1 1 3U/1. X-ray of the renal tract revealed no evidence of calcification. He was asymptomatic and had no palpabl...
متن کامل'Surgical cure' for non-parathyroid hypercalcemia
BACKGROUND Sarcoidosis is a granulomatous disease of unknown aetiology. Over 90% patients of sarcoidosis present with pulmonary findings. Other organs such as lymph nodes, skin, and joints may be involved. Isolated granulomatous disease confined to the spleen is rare. CASE PRESENTATION This report documents a rare case of isolated granulomatous disease of spleen presenting as hypercalcemia. A...
متن کاملEffects of acute and chronic hypercalcemia on parathyroid function and circulating parathyroid hormone molecular forms.
Bas et al. (1), in this issue, have demonstrated that acute hypercalcemic clamp over 2 h in rabbits reduces the subsequent intact (I) parathyroid hormone (PTH) response to hypocalcemia by 50%, while chronic hypercalcemia, secondary to experimental renal failure in the same animal model, fails to reduce the I-PTH response to hypocalcemia. These results raise questions about the acute and chronic...
متن کاملParathyroid hormone without parathyroid glands.
In mammals, PTH is a component in a complex signaling system involving three structurally related ligands and two G protein-coupled receptors, which share significant amino acid sequence homology (Fig. 1). PTH is a peptide hormone comprising 84 amino acids that is made by the parathyroid glands (and to a much smaller extend by the thymus) and acts through the PTH/PTH-related peptide (PTHrP) rec...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1964
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.119.3.467